The aim of this study was to investigate the relationship between self-compassion, sensitivity to rejection and irrational beliefs in predicting depression and anxiety in divorced women. The study was a cross-sectional descriptive one. The population included all divorced women in Arak and the sample was obtained by available sampling. Depression Anxiety Stress Scales (Levibond, 1995), self-compassion scale (Raes, 2011), Irrational Beliefs Test (Jones, 1968), and Rejection Sensitivity Questionnaire (Downey & Feldman, 1996) were used to collect data. The data were analyzed using correlation coefficient and stepwise regression analysis. The results of the correlation coefficients showed that there is a direct and positive relationship between sensitivity as well as irrational beliefs and depression and an inverse relationship between self-compassion and depression (p<0/01). Also, the relationship between sensitivity to rejection and irrational beliefs with anxiety was direct and the relationship between self-compassion and anxiety was inverse (p<0/01). The results of the regression analysis also showed that irrational beliefs predicts 26.9% (p<0.01) and sensitivity to rejection 2.8% (p<0.05) of depression changes. Also, sensitivity to rejection predicts 22.3% (p<0.01) and self-compassion 5.7% (p<0.01) of anxiety changes. Accordingly, sensitivity to rejection is an important construct in predicting anxiety and depression among divorced women. At the same time, irrational beliefs are more important in experiencing depression and self-compassion in experiencing anxiety in this group of people.