The present study was conducted to investigate the effectiveness of cognitive behavioral therapy on the psychological flexibility of women suffering from marital burnout. The study was semi-experimental, using pre-test-post-test with a control group. The statistical population included all married women with marital dissatisfaction who referred to counseling centers in the District 17 of Tehran in 2022. From this statistical population, 30 people were selected by available sampling and randomly assigned to two groups of 15 people (15 people in the experimental group and 15 people in the control group). The cognitive flexibility inventory by Dennis and Vanderwal (2010) was used to collect data. The cognitive-behavioral counseling sessions were organized in 8 sessions, lasting 4 weeks with two sessions a week, and with each session being held in 90 minutes. The data were analyzed by analysis of covariance. The results of the data analysis showed that cognitive behavioral therapy was effective on the psychological flexibility of women suffering from marital heartbreak in the experimental group, with the women in the experimental group showed higher psychological flexibility than the women in the control group. Based on the results of this study,  health professionals can use cognitive behavioral therapy to improve psychological flexibility in women suffering from marital burnout.